CHENG, Wan Kiu Winkey

CHENG, Wan Kiu Winkey

he/him

Bachelor in Biomedical Engineering minoring Neuroscience, researching memory formation, synaptic plasticity, and neurodegenerative diseases through biological and artificial neural network approaches. Actively seeking research opportunities in Hong Kong.

Posts by Tags

3d-printing

生物醫學系研討會：看大神如何把微流控變成「懶人科技」

1 minute read

Published:

Summary:
Professor David Juncker from McGill University presented an inspiring seminar on minimalist microfluidics technologies. Three groundbreaking innovations were presented: (1) Capillary microfluidics - using natural capillary action instead of pumps for fluid manipulation, enabling battery-free diagnostics in remote areas; (2) LCD 3D printing - democratizing microfluidic chip fabrication with consumer-grade 3D printers (25-50μm resolution), reducing costs from thousands to tens of dollars and production time from days to hours; (3) Brownian motion detector - leveraging molecular thermal motion for ultra-sensitive, zero-energy biosensing. The talk emphasizes “elegant simplicity” in engineering design - harnessing natural physical phenomena rather than fighting them, making advanced diagnostics accessible worldwide.

biomedical-engineering

How Tsinghua’s Chemistry Wizards Are “Building” Proteins Like LEGO Blocks

10 minute read

Published:

🎯 The Big Reveal Up Front: Chemistry Just Leveled Up!
Professor Liu Lei hosted a seminar on de novo chemical protein synthesis at City University of Hong Kong. His lab at Tsinghua University has developed a comprehensive methodological framework that transcends biological constraints, enabling synthesis of custom-designed proteins up to 3,000 amino acids—covering 99.7% of all natural proteins. Three key innovations form this framework: (1) peptide hydrazide ligation for convergent synthesis without protecting groups; (2) reversible auxiliary strategies using charged or carbohydrate tags to prevent aggregation during synthesis; and (3) artificial ligase enzymes that catalyze protein assembly in denaturing conditions. These techniques unlock “beyond-biology” applications including mirror-image D-proteins, site-specifically modified therapeutic targets, and rapid drug candidate synthesis. This post explores the chemistry breakthroughs, pharmaceutical implications, and synergies with AI-driven drug discovery that make chemical protein synthesis a game-changer for biomedical research.

生物醫學系研討會：看大神如何把微流控變成「懶人科技」

1 minute read

Published:

Summary:
Professor David Juncker from McGill University presented an inspiring seminar on minimalist microfluidics technologies. Three groundbreaking innovations were presented: (1) Capillary microfluidics - using natural capillary action instead of pumps for fluid manipulation, enabling battery-free diagnostics in remote areas; (2) LCD 3D printing - democratizing microfluidic chip fabrication with consumer-grade 3D printers (25-50μm resolution), reducing costs from thousands to tens of dollars and production time from days to hours; (3) Brownian motion detector - leveraging molecular thermal motion for ultra-sensitive, zero-energy biosensing. The talk emphasizes “elegant simplicity” in engineering design - harnessing natural physical phenomena rather than fighting them, making advanced diagnostics accessible worldwide.

biosensors

生物醫學系研討會：看大神如何把微流控變成「懶人科技」

1 minute read

Published:

Summary:
Professor David Juncker from McGill University presented an inspiring seminar on minimalist microfluidics technologies. Three groundbreaking innovations were presented: (1) Capillary microfluidics - using natural capillary action instead of pumps for fluid manipulation, enabling battery-free diagnostics in remote areas; (2) LCD 3D printing - democratizing microfluidic chip fabrication with consumer-grade 3D printers (25-50μm resolution), reducing costs from thousands to tens of dollars and production time from days to hours; (3) Brownian motion detector - leveraging molecular thermal motion for ultra-sensitive, zero-energy biosensing. The talk emphasizes “elegant simplicity” in engineering design - harnessing natural physical phenomena rather than fighting them, making advanced diagnostics accessible worldwide.

capillary-microfluidics

生物醫學系研討會：看大神如何把微流控變成「懶人科技」

1 minute read

Published:

Summary:
Professor David Juncker from McGill University presented an inspiring seminar on minimalist microfluidics technologies. Three groundbreaking innovations were presented: (1) Capillary microfluidics - using natural capillary action instead of pumps for fluid manipulation, enabling battery-free diagnostics in remote areas; (2) LCD 3D printing - democratizing microfluidic chip fabrication with consumer-grade 3D printers (25-50μm resolution), reducing costs from thousands to tens of dollars and production time from days to hours; (3) Brownian motion detector - leveraging molecular thermal motion for ultra-sensitive, zero-energy biosensing. The talk emphasizes “elegant simplicity” in engineering design - harnessing natural physical phenomena rather than fighting them, making advanced diagnostics accessible worldwide.

chemical-biology

How Tsinghua’s Chemistry Wizards Are “Building” Proteins Like LEGO Blocks

10 minute read

Published:

🎯 The Big Reveal Up Front: Chemistry Just Leveled Up!
Professor Liu Lei hosted a seminar on de novo chemical protein synthesis at City University of Hong Kong. His lab at Tsinghua University has developed a comprehensive methodological framework that transcends biological constraints, enabling synthesis of custom-designed proteins up to 3,000 amino acids—covering 99.7% of all natural proteins. Three key innovations form this framework: (1) peptide hydrazide ligation for convergent synthesis without protecting groups; (2) reversible auxiliary strategies using charged or carbohydrate tags to prevent aggregation during synthesis; and (3) artificial ligase enzymes that catalyze protein assembly in denaturing conditions. These techniques unlock “beyond-biology” applications including mirror-image D-proteins, site-specifically modified therapeutic targets, and rapid drug candidate synthesis. This post explores the chemistry breakthroughs, pharmaceutical implications, and synergies with AI-driven drug discovery that make chemical protein synthesis a game-changer for biomedical research.

drug-discovery

How Tsinghua’s Chemistry Wizards Are “Building” Proteins Like LEGO Blocks

10 minute read

Published:

🎯 The Big Reveal Up Front: Chemistry Just Leveled Up!
Professor Liu Lei hosted a seminar on de novo chemical protein synthesis at City University of Hong Kong. His lab at Tsinghua University has developed a comprehensive methodological framework that transcends biological constraints, enabling synthesis of custom-designed proteins up to 3,000 amino acids—covering 99.7% of all natural proteins. Three key innovations form this framework: (1) peptide hydrazide ligation for convergent synthesis without protecting groups; (2) reversible auxiliary strategies using charged or carbohydrate tags to prevent aggregation during synthesis; and (3) artificial ligase enzymes that catalyze protein assembly in denaturing conditions. These techniques unlock “beyond-biology” applications including mirror-image D-proteins, site-specifically modified therapeutic targets, and rapid drug candidate synthesis. This post explores the chemistry breakthroughs, pharmaceutical implications, and synergies with AI-driven drug discovery that make chemical protein synthesis a game-changer for biomedical research.

innovation

生物醫學系研討會：看大神如何把微流控變成「懶人科技」

1 minute read

Published:

Summary:
Professor David Juncker from McGill University presented an inspiring seminar on minimalist microfluidics technologies. Three groundbreaking innovations were presented: (1) Capillary microfluidics - using natural capillary action instead of pumps for fluid manipulation, enabling battery-free diagnostics in remote areas; (2) LCD 3D printing - democratizing microfluidic chip fabrication with consumer-grade 3D printers (25-50μm resolution), reducing costs from thousands to tens of dollars and production time from days to hours; (3) Brownian motion detector - leveraging molecular thermal motion for ultra-sensitive, zero-energy biosensing. The talk emphasizes “elegant simplicity” in engineering design - harnessing natural physical phenomena rather than fighting them, making advanced diagnostics accessible worldwide.

microfluidics

生物醫學系研討會：看大神如何把微流控變成「懶人科技」

1 minute read

Published:

Summary:
Professor David Juncker from McGill University presented an inspiring seminar on minimalist microfluidics technologies. Three groundbreaking innovations were presented: (1) Capillary microfluidics - using natural capillary action instead of pumps for fluid manipulation, enabling battery-free diagnostics in remote areas; (2) LCD 3D printing - democratizing microfluidic chip fabrication with consumer-grade 3D printers (25-50μm resolution), reducing costs from thousands to tens of dollars and production time from days to hours; (3) Brownian motion detector - leveraging molecular thermal motion for ultra-sensitive, zero-energy biosensing. The talk emphasizes “elegant simplicity” in engineering design - harnessing natural physical phenomena rather than fighting them, making advanced diagnostics accessible worldwide.

protein-synthesis

How Tsinghua’s Chemistry Wizards Are “Building” Proteins Like LEGO Blocks

10 minute read

Published:

🎯 The Big Reveal Up Front: Chemistry Just Leveled Up!
Professor Liu Lei hosted a seminar on de novo chemical protein synthesis at City University of Hong Kong. His lab at Tsinghua University has developed a comprehensive methodological framework that transcends biological constraints, enabling synthesis of custom-designed proteins up to 3,000 amino acids—covering 99.7% of all natural proteins. Three key innovations form this framework: (1) peptide hydrazide ligation for convergent synthesis without protecting groups; (2) reversible auxiliary strategies using charged or carbohydrate tags to prevent aggregation during synthesis; and (3) artificial ligase enzymes that catalyze protein assembly in denaturing conditions. These techniques unlock “beyond-biology” applications including mirror-image D-proteins, site-specifically modified therapeutic targets, and rapid drug candidate synthesis. This post explores the chemistry breakthroughs, pharmaceutical implications, and synergies with AI-driven drug discovery that make chemical protein synthesis a game-changer for biomedical research.

seminar-notes

How Tsinghua’s Chemistry Wizards Are “Building” Proteins Like LEGO Blocks

10 minute read

Published:

🎯 The Big Reveal Up Front: Chemistry Just Leveled Up!
Professor Liu Lei hosted a seminar on de novo chemical protein synthesis at City University of Hong Kong. His lab at Tsinghua University has developed a comprehensive methodological framework that transcends biological constraints, enabling synthesis of custom-designed proteins up to 3,000 amino acids—covering 99.7% of all natural proteins. Three key innovations form this framework: (1) peptide hydrazide ligation for convergent synthesis without protecting groups; (2) reversible auxiliary strategies using charged or carbohydrate tags to prevent aggregation during synthesis; and (3) artificial ligase enzymes that catalyze protein assembly in denaturing conditions. These techniques unlock “beyond-biology” applications including mirror-image D-proteins, site-specifically modified therapeutic targets, and rapid drug candidate synthesis. This post explores the chemistry breakthroughs, pharmaceutical implications, and synergies with AI-driven drug discovery that make chemical protein synthesis a game-changer for biomedical research.

生物醫學系研討會：看大神如何把微流控變成「懶人科技」

1 minute read

Published:

Summary:
Professor David Juncker from McGill University presented an inspiring seminar on minimalist microfluidics technologies. Three groundbreaking innovations were presented: (1) Capillary microfluidics - using natural capillary action instead of pumps for fluid manipulation, enabling battery-free diagnostics in remote areas; (2) LCD 3D printing - democratizing microfluidic chip fabrication with consumer-grade 3D printers (25-50μm resolution), reducing costs from thousands to tens of dollars and production time from days to hours; (3) Brownian motion detector - leveraging molecular thermal motion for ultra-sensitive, zero-energy biosensing. The talk emphasizes “elegant simplicity” in engineering design - harnessing natural physical phenomena rather than fighting them, making advanced diagnostics accessible worldwide.